Решение:
\[ \frac{3}{4} - \frac{5}{16} = \frac{3 \cdot 4}{4 \cdot 4} - \frac{5}{16} = \frac{12}{16} - \frac{5}{16} = \frac{12-5}{16} = \frac{7}{16} \]
\[ \frac{7}{16} \cdot \frac{8}{21} = \frac{7 \cdot 8}{16 \cdot 21} \]
\[ \frac{7}{16} \cdot \frac{8}{21} = \frac{7}{2 \cdot 8} \cdot \frac{8}{3 \cdot 7} = \frac{1}{2} \cdot \frac{1}{3} = \frac{1}{6} \]
Ответ: 1/6